Monacor Pa 900 Manual Meat
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An animate surface treatment composition according to claim 1, which exhibits a log10 reduction of at least about 2 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces. An animate surface treatment composition according to claim 12, which exhibits a log10 reduction of at least about 3 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces. An animate surface treatment composition according to claim 13, which exhibits a log10 reduction of at least about 4 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces. An animate surface treatment composition according to claim 13, which exhibits a log10 reduction of at least about 2 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces. An animate surface treatment composition according to claim 13, which exhibits a log10 reduction of at least about 3 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces. An animate surface treatment composition according to claim 16, which exhibits a log10 reduction of at least about 4 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces.
An animate surface treatment composition according to claim 3, which exhibits a log10 reduction of at least about 2 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces. An animate surface treatment composition according to claim 18, which exhibits a log10 reduction of at least about 3 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces. An animate surface treatment composition according to claim 19, which exhibits a log10 reduction of at least about 4 against adenovirus and/or poliovirus type 1 (Sabin) (“PV1”) when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces. The present invention relates to personal care compositions which comprise metal ions selected from copper ions and/or zinc ions, which compositions exhibit a microbicidal benefit when applied to animate surfaces, e.g. Dermal and/or topical surfaces including skin and hair. The aqueous alcoholic compositions provide a surprisingly high degree of microbicidal activity against various undesirable microorganisms (sometimes referred to as ‘pathogens’) including various bacteria, mycobacteria, viruses, and fungi.
While ethanol and other monohydric alcohols are known to the art as having a beneficial microbicidal benefit, at the same time it is a volatile organic compound (“VOC”) and there is a substantial interest in regulating the use of ethanol (as well as other volatile organic compounds) in products wherein the ethanol or other VOC is exposed to the environment. Such regulatory interests are, however, completely contrary to the technical benefits provided by ethanol and other monohydric alcohols, and in particular ethanol, as a microbicidal agent, as increased levels of ethanol in a composition have long been known to find increased microbicidal benefits against undesirable microorganisms. Further, while ethanol and other monohydric alcohols are known to the art as having a beneficial microbicidal benefit they are not without undesirable effects as well; topical compositions with higher amounts of ethanol are known to cause undesirable drying of the skin, and foaming personal care compositions are difficult to formulate where such comprise higher amounts of ethanol. The technical art has proposed several compositions which are cited to provide some degree of microbicidal/germicidal/antimicrobial efficacy, at the same time to comprise reduced amounts of ethanol and other monohydric alcohols while still providing an appreciable microbicidal benefit.
However, these compositions are not wholly successful in providing microbicidal/germicidal/antimicrobial benefit against a broad range of undesirable microorganisms, and in particular in providing effective microbicidal benefit against particularly difficult to eradicate microorganisms including non-enveloped viruses, and in particular polioviruses e.g., poliovirus type 1 (Sabin). As is recognized in the art, demonstrated eradication of poliovirus is highly advantageous as such compositions would not only be effective in controlling this dangerous microorganism but at the same time such a high level of efficacy would also be recognized against relatively easier to eradicate microorganisms including but not limited to bacteria, mycobacteria, other non-enveloped and enveloped virus strains including fungi. The prior art discloses various compositions which are cited to provide a microbicidal effect.
3,992,146 are disclosed germicidal and antifungal compositions which are based on aqueous solutions of a copper compound and a surfactant. The surfactants disclosed are primarily anionic surfactants based on sulfate or sulfonated organic compounds. The use of ethanol or of specific pH ranges are not clearly disclosed or demonstrated. 5,180,749 describes largely aqueous compositions comprising about 65-88% wt. Water and which include as further essential constituents both about 10-30% wt.
Ethanol with about 2-5% wt. Benzyl alcohol. However, the use of water soluble metal salts is not disclosed nor is the pH of the compositions disclosed.
The compositions were tested against Staphylococcus aureus, Salmonella choleraesuis, Pseudomonas aeruginosa, rhinovirus type 39, herpes simplex 1, herpes simplex 2, adenovirus type 2, respiratory syncytial, influenza A2, influenza B, human rotavirus, Mycobacterium tuberculosis var. Bovis, as well as fungi of types Aspergillus niger and Trichopython mentgrophytes. In that patent, when contrasting the data from Table B to the data from Table A, the necessary inclusion of benzyl alcohol in conjunction with ethanol in order to achieve increased microbicidal efficacy is shown.
The poor microbicidal efficacy of compositions comprising 30% wt. Ethanol and water and where benzyl alcohol is absent is demonstrated on Table B. 5,728,404 discloses certain virucidal disinfectant compositions which are described as including one or more C 1-C 4 aliphatic alcohols, 0.1-1% wt. Of a hydrolized metal ion, and water. Compositions comprising ethyl alcohol and isopropyl alcohol and ratios of 8:1 to 1:1 are noted to be particularly effective and preferred.
While the document alleges that the amount of the aliphatic alcohol may be in the range of 40%-90% wt., such is not demonstrated as in the four examples provided the amount of the aliphatic alcohols are respectively 80% wt., 70% wt., 80% wt. Furthermore, when formed as described in that document, the composition according to Example 1 of this patent document exhibited a pH of 5.48, the composition of Example 2 exhibited a pH of 5.63, and the composition of Example 3 exhibited a pH of 5.63, which indicates that the foregoing compositions consistently demonstrated an acidic pH. 6,034,043 and 6,017,861 disclose liquid skin cleaning compositions comprising (1) a so-called mild surfactant system of which at least 10% wt. Of which (and which preferably at least 25% wt. Of which), is an anionic surfactant, (2) 0.1-10% wt.
Of a polyvalent cation or cations selected from zinc, copper, tin, aluminum, cobalt, nickel, chromium, titanium, and/or manganese and mixtures thereof, and (3) 1-99% wt. Water wherein the cations provide antimicrobial activity. These patents suggest that microbiocidal activity of the liquid skin cleaning compositions was due to the combination of the mild surfactant system with the polyvalent cation or cations whereas the polyvalent cation or cations themselves did not provide a microbiocidal benefit. Further, none of the demonstrated compositions include lower alkyl monohydric alcohols. 8,119,115 discloses certain antiviral compositions which are cited to be useful against non-enveloped viruses. The compositions necessarily include an alcohol component which is cited to be present in at least 50% wt.
But is preferably present in amounts of at least 60% wt, and more preferably at least 65% wt. And even higher amounts, in conjunction with a so-called enhancer component which may be a cationic oligomer or polymer, such as cationic cationic polysaccharides, cationic copolymers of saccharides and synthetic cationic monomers, and synthetic cationic oligomers or polymers which include cationic polyalkylenimines, cationic ethoxy polyalkylene imines, cationic polyN-3-dialkylammonio)alkylN′ 3-alkyleneoxyalkylene dialkylammonio)alkylurea dichloride, vinyl caprolactam/VP/dialkylaminoalkyl alkylate copolymers, and polyquatemium polymers. Notably all of the example compositions tested included 70% wt.
Or more of ethanol. 8,450,378, based on a continuation-in-part patent application of U.S. 8,119,115, and additionally discloses that zinc or copper compounds may be included in addition to the alcohol and cationic oligomer or polymer compounds. As is known to the art, oligomers are essentially short chained polymer compounds which necessarily have a number of repeating units. Similarly to the related application, exemplified compositions of the invention comprise 62% wt., but predominantly comprise 70%-78% wt. 8,470,755 discloses certain liquid cleaning and disinfecting compositions which necessarily comprise an inorganic salt which is preferably a divalent zinc salt, and a linear alkyl alkyl nucleophilic surfactant such as a linear alkyl chain amine oxide. The example compositions demonstrate only that the addition of divalent zinc ions (Zn) provide an increased antimicrobial benefit against E.
Aureus and P. Aeroginosa when used in conjunction with a linear C 12-14 alkyl dimethyl amine oxide compound, versus a cocoamidopropyl dimethyl amine oxide compound, a symmetrically branched dimethyl amine oxide compound or a non-symmetrically amine oxide with a methyl branched moiety, the latter three amine oxide compounds which did not demonstrate any improvement in antibacterial efficacy against the same tested microorganisms. US 20 discloses aqueous alcoholic compositions which comprise 40% wt.-70% wt. Of a lower alkanol, optionally a quaternary ammonium cationic compound which itself provides germicidal properties, water and a pH adjusting agent to provide a final pH of between 7 and 13. The compositions are shown to be effective against various microorganisms including gram-positive and gram-negative types of pathogenic bacteria, as well as Poliovirus (Type 1) at a 10 minute contact time. The reference however makes no mention of the use of copper ions in the compositions.
US 20 discloses compositions which are cited to be effective against non-enveloped virus particles. The compositions comprise a C 1-C 6 alcohol and an efficacy-enhancing amount of one or more of: cationic oligomers and polymers, proton donors, chaotropic agents, and mixtures thereof with the proviso that when the compositions include a proton donor that a cationic oligomer or polymer is also present.
The cationic oligomers and polymers disclosed are defined to include cationic polyalkylene imines, cationic ethoxy polyalkylene imines, cationic polyN-3-(dialkylammonio)alkylN′3-(alkyleneoxyalkylene dialkylammonio)alkylurea dichloride, vinyl caprolactam/VP/dialkylaminoalkyl alkylate copolymers and polyquaternium copolymers. The example compositions disclosed in the reference demonstrate compositions having 62% wt. And even greater amounts of the C 1-C 6 alcohol as being present. US 20 discloses certain surface sanitizer compositions which are recited to include 50-90% wt. Of an alcohol component, 10-50% wt. Of water, an acid component to maintain the pH of the composition between 2-5, and 0.05-5% wt. Of a multivalent cation constituent.
The multivalent cation constituent may be a one of a selected list of polymers, a metal ion or a metal compound. The compositions may further optionally include one or more further constituents including oxidative agents, plant derived alkenes or essential oils, emollients, humectants, lubricants and one or more antimicrobial compounds, e.g., quaternary ammonium compounds. The single example of US 20 tested demonstrates that a composition having 78% wt. Ethanol exhibits efficacy against Candida albicans, Aspergillus niger, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and adenovirus type 5. Further examples disclosed in US 20 are not disclosed to have been tested against any microorganisms. The treatment of biofilms by compositions which include certain heavy metals are known from US 20.
The treatment steps require that the biofilms be contacted with the said compositions for 4 hours or more. The biofilms are defined to be conglomerates of microbial organisms embedded in highly hydrated matricies of exopolymers, typically polysaccharides, and other macromolecules. US 20 discloses certain antibacterial formulations which comprise a water-soluble copper compound, a water-soluble ammonium agent, and a water-soluble acid when the composition necessarily has an acidic pH. US 20 discloses methods and compositions for disinfecting hard surfaces which are aqueous compositions which comprise 40% wt.-70% wt. Of an alcohol constituent selected from the group consisting of methanol, ethanol, n-propanol, isopropanol, n-butanol, benzyl alcohol, and mixtures thereof and a pH in the range of from about 7.0-14.0. The compositions may include further optional constituents, including ancillary antimicrobial agents, and surfactants, but the use of water soluble metal salts is not disclosed.
US 20, which is related to both U.S. 8,119,115 and 8,450,378 is of similar scope, but discloses several additional example compositions in addition to those previously disclosed in U.S. 8,450,378, which further example compositions include 74.1% ethanol, a Polyquaternium polymer, and PEG-10 dimethicone and PEG-12 dimethicones, with a demonstrated effect against adenovirus and hepatitis A. Notwithstanding these various known art compositions, there is still an urgent need in the art to produce treatment compositions, adapted for the control or eradication of undesired microorganisms where such treatment compositions comprise reduced amounts of VOC, and in particular aliphatic alcohols which provide a microbicidal effect such as ethanol, yet which compositions are highly effective against particularly difficult to eradicate undesired microorganisms, especially poliovirus, particularly where the treatment compositions are applied to an animate surface.
Where at least one of R 1, R 2, R 3 and R 4 is a alkyl, aryl or alkylaryl substituent of from 6 to 26 carbon atoms, and the entire cation portion of the molecule has a molecular weight of at least 165. The alkyl substituents may be long-chain alkyl, long-chain alkoxyaryl, long-chain alkylaryl, halogen-substituted long-chain alkylaryl, long-chain alkylphenoxyalkyl, arylalkyl, etc. The remaining substituents on the nitrogen atoms other than the abovementioned alkyl substituents are hydrocarbons usually containing no more than 12 carbon atoms. The substituents R 1, R 2, R 3 and R 4 may be straight-chained or may be branched, but are preferably straight-chained, and may include one or more amide, ether or ester linkages.
Monacor Pa 900 Manual Meat Bar
The counterion X may be any salt-forming anion which permits for the solubility or miscibility of the quaternary ammonium complex within the treatment composition. Exemplary quaternary ammonium salts within the above description include the alkyl ammonium halides such as cetyl trimethyl ammonium bromide, alkyl aryl ammonium halides such as octadecyl dimethyl benzyl ammonium bromide, N-alkyl pyridinium halides such as N-cetyl pyridinium bromide, and the like. Other suitable types of quaternary ammonium salts include those in which the molecule contains either amide, ether or ester linkages such as octyl phenoxy ethoxy ethyl dimethyl benzyl ammonium chloride, N-(laurylcocoaminoformylmethyl)-pyridinium chloride, and the like.
Other very effective types of quaternary ammonium compounds which are useful as germicides include those in which the hydrophobic radical is characterized by a substituted aromatic nucleus as in the case of lauryloxyphenyltrimethyl ammonium chloride, cetylaminophenyltrimethyl ammonium methosulfate, dodecylphenyltrimethyl ammonium methosulfate, dodecylbenzyltrimethyl ammonium chloride, chlorinated dodecylbenzyltrimethyl ammonium chloride, and the like. Preferred quaternary ammonium compounds which exhibit an microbicidal effect, viz., act as germicides, and which are useful in the practice of the present invention include those which have the structural formula.
In which the C 9H 19 group in the latter formula is a mixture of branched chained isomers, and x indicates an average number of ethoxy units in the side chain. Particularly suitable non-ionic ethoxylated octyl and nonyl phenols include those having from about 7 to about 13 ethoxy groups. Such compounds are commercially available under the trade name Triton® X (Dow Chemical, Midland, Mich.), as well as under the tradename Igepal® (Rhodia, Princeton, N.J.). One exemplary and particularly preferred nonylphenol ethoxylate is Igepal® CO-630. Still further examples of suitable nonionic surfactants which may be advantageously included in the inventive compositions are alkoxy block copolymers, and in particular, compounds based on ethoxy/propoxy block copolymers. Polymeric alkylene oxide block copolymers include nonionic surfactants in which the major portion of the molecule is made up of block polymeric C2-C4 alkylene oxides. Such nonionic surfactants, while preferably built up from an alkylene oxide chain starting group, can have as a starting nucleus almost any active hydrogen containing group including, without limitation, amides, phenols, thiols and secondary alcohols.
One group of such useful nonionic surfactants containing the characteristic alkylene oxide blocks are those which may be generally represented by the formula (A): HO-(EO) x(PO) y(EO) z—H (A) where EO represents ethylene oxide, PO represents propylene oxide,. y equals at least 15,. (EO) x+y equals 20 to 50% of the total weight of said compounds, and, the total molecular weight is preferably in the range of about 2000 to 15,000. Another group of nonionic surfactants for use in the new inventive compositions can be represented by the formula (B): R-(EO,PO) a(EO,PO) b—H (B) wherein R is an alkyl, aryl or aralkyl group, where the R group contains 1 to 20 carbon atoms, the weight percent of EO is within the range of 0 to 45% in one of the blocks a, b, and within the range of 60 to 100% in the other of the blocks a, b, and the total number of moles of combined EO and PO is in the range of 6 to 125 moles, with 1 to 50 moles in the PO rich block and 5 to 100 moles in the E0 rich block.
Further nonionic surfactants which in general are encompassed by formula (B) include butoxy derivatives of propylene oxide/ethylene oxide block polymers having molecular weights within the range of about 2000-5000. Still further useful nonionic surfactants containing polymeric butoxy (BO) groups can be represented by formula (C) as follows: RO—(BO) n(EO) x—H (C) wherein R is an alkyl group containing 1 to 20 carbon atoms, n is about 5-15 and x is about 5-15. Also useful as the nonionic block copolymer surfactants, which also include polymeric butoxy groups, are those which may be represented by the following formula (D): HO-(EO) x(BO) n(EO) y—H (D) wherein n is about 5-15, preferably about 15, x is about 5-15, preferably about 15, and y is about 5-15, preferably about 15.
Still further useful nonionic surfactants include ethoxylated derivatives of propoxylated ethylene diamine, which may be represented by the following formula. Where (EO) represents ethoxy, (PO) represents propoxy, the amount of (PO) x is such as to provide a molecular weight prior to ethoxylation of about 300 to 7500, and the amount of (EO) y is such as to provide about 20% to 90% of the total weight of said compound. Further examples of useful nonionic surfactants are one or more amine oxides. Exemplary amine oxides include: A) Alkyl di(lower alkyl) amine oxides in which the alkyl group has about 10-20, and preferably 12-16 carbon atoms, and can be straight or branched chain, saturated or unsaturated. The lower alkyl groups include between 1 and 7 carbon atoms. Examples include lauryl dimethyl amine oxide, myristyl dimethyl amine oxide, and those in which the alkyl group is a mixture of different amine oxide, dimethyl cocoamine oxide, dimethyl (hydrogenated tallow) amine oxide, and myristyl/palmityl dimethyl amine oxide; B) Alkyl di(hydroxy lower alkyl) amine oxides in which the alkyl group has about 10-20, and preferably 12-16 carbon atoms, and can be straight or branched chain, saturated or unsaturated.
Examples are bis(2-hydroxyethyl) cocoamine oxide, bis(2-hydroxyethyl) tallowamine oxide; and bis(2-hydroxyethyl) stearylamine oxide; C) Alkylamidopropyl di(lower alkyl) amine oxides in which the alkyl group has about 10-20, and preferably 12-16 carbon atoms, and can be straight or branched chain, saturated or unsaturated. Examples are cocoamidopropyl dimethyl amine oxide and tallowamidopropyl dimethyl amine oxide; and D) Alkylmorpholine oxides in which the alkyl group has about 10-20, and preferably 12-16 carbon atoms, and can be straight or branched chain, saturated or unsaturated. Preferably the amine oxide constituent is an alkyl di(lower alkyl) amine oxide as denoted above and which may be represented by the following structure. In which, R represents a C 4 to C 24 alkyl group, and is preferably a C10 to C16 alkyl group, R1 and R2 independently represent a C 1 to C 8 alkyl group, is preferably —CH 2CH 2— or —CH 2CH 2CH 2—, and M may be any salt-forming anion which permits water solubility or water miscibility of the compound, e.g., chloride, bromide, methosulfate, ethosulfate, lactate, saccharinate, acetate or phosphate. Such compounds are presently commercially available, such as those marketed in the Tomamine Amphoteric series of amphoteric surfactants, ex. Air Products Inc.
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While the one or more detersive surfactants may be present in any effective amount which may be observed to improve the microbicidal efficacy of the system of the essential constituents, these one or more surfactants, when present, are advantageously present in an amount of from about 0.001-99% wt., preferably from about 0.1-60% wt., based on the total weight of the treatment composition (or microbicidal system) within which they are present. In certain preferred embodiments the one or more detersive surfactants comprise in excess of 1% wt.
Of an animate treatment composition, preferably in excess of 1% wt. To about 30% wt., and preferably comprise at least about 5% wt. Of an animate treatment composition of which they form a part. Wherein n is 0, or is an integer of 1 or greater, preferably n=0-12, more preferably 0-5, and optionally one of the methyl groups of the foregoing linear silicone formula may be replaced with an alkyl group (e.g. Of 2 to 10 carbon atoms) to provide an alkylmethylsiloxane. Such linear and cyclic silicones comprise octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, hexamethyldisiloxane, 3-hexylheptamethyltrisiloxane, octamethyltrisiloxane, dodecamethylpentasiloxane, and mixtures thereof, and include commercially available materials such as the Dow Corning 200 Fluid, Dow Corning 244 Fluid, Dow Corning 245 Fluid, Dow Corning 344 Fluid, DM Fluid 0.65 cs, DM Fluid 1.5 cs, DM Fluid 2.0 cs, DC 2-1184 and DC 2-1731, all of which are available from Dow Corning or other commercial sources. Further examples of volatile oils include various straight or branched chain paraffinic hydrocarbons having 5 to 40 carbon atoms, more preferably 8-20 carbon atoms.
Preferred paraffinic hydrocarbons include pentane, hexane, heptane, decane, dodecane, tetradecane, tridecane, and C 8-C 20 isoparaffins such as isodecane, preferred of which are those having a molecular weight of 70-225, and a boiling point in the range of 30-320° C., preferably 60-260° C. Such include materials currently available under the tradename Isopar® (ex Exxon) as well as under the Permethyl® tradename (ex. Permethyl Corp.) Examples of non-volatile oils include non-volatile liquid oils such as silicones, esters, and the like. In the case where it is desired to make long wearing cosmetic products, if the nonvolatile oils are too heavy or greasy it may hamper the long wearing characteristics of the invention. In such a case, the viscosity of the nonvolatile oils, if present, should range from about 11-1000, preferably less than 100 centipoise, most preferably less than about 50 centipoise at 25° C. Examples of such oils include polyalkylsiloxanes, polyarylsiloxanes, and polyethersiloxanes, as well as non-volatile silicones such as dimethicone, phenyl trimethicone, dimethicone copolyol, and the like. Further non-volatile oils include lower viscosity organic liquids including saturated or unsaturated, substituted or unsubstituted branched or linear or cyclic organic compounds that are liquid under ambient conditions, viz., at normal atmospheric pressure and a temperature of about 20-25° C.
Such non-volatile oils generally have a viscosity of greater than 10 centipoise at 25° C. And may range in viscosity up to about 1,000,000 centipoise at said temperature. Further examples of non-volatile oils include naturally occurring glyceryl esters of fatty acids, or triglycerides. Both vegetable and animal sources may be used. Examples of such oils include castor oil, lanolin oil, C 10-C 18 triglycerides, caprylic/capric/triglycerides, coconut oil, corn oil, cottonseed oil, linseed oil, mink oil, olive oil, palm oil, illipe butter, rapeseed oil, soybean oil, sunflower seed oil, walnut oil, and the like.
Also useful are synthetic or semi-synthetic glyceryl esters, e.g. Fatty acid mono-, di-, and triglycerides which are natural fats or oils that have been modified, for example, acetylated castor oil, or mono-, di- or triesters of polyols such as glyceryl stearate, diglyceryl diiosostearate, polyglyceryl-4 isostearate, polyglyceryl-6 ricinoleate, glyceryl dioleate, glyceryl diisostearate, glyceryl trioctanoate, diglyceryl distearate, glyceryl linoleate, glyceryl myristate, glyceryl isostearate, PEG castor oils, PEG glyceryl oleates, PEG glyceryl stearates, PEG glyceryl tallowates, and the like. Further useful non-volatile oils include non-volatile silicone oils.
By way of non-limiting example such include non-volatile silicone oils which may be water insoluble such as amine functional silicones such as amodimethicone; phenyl substituted silicones such as bisphenylhexamethicone, phenyl trimethicone, or polyphenylmethylsiloxane; dimethicone, alkyl substituted dimethicones, and mixtures thereof, as well as those which are water soluble such as dimethicone copolyol, dimethiconol, and the like. Further useful oils include various fluorinated oils such as fluorinated silicones, such as trimethylsilyl endcapped fluorosilicone oil, polytrifluoropropylmethylsiloxanes, fluorinated esters, perfluoropolyethers, and the like. Any one or more of the foregoing volatile oils or non-volatile oils may be present in the animate surface treatment compositions in any effective amount in order to provide a desired technical or aesthetic benefit. Advantageously, when present, one or more of the foregoing volatile oils or non-volatile oils may is present in an amount of at least about 0.01% wt., preferably is present in an amount of from about 0.001% wt. To about 10% wt., based on the total weight of the composition of which the one or more volatile oils or non-volatile oils form a part. The treatment compositions of the invention may include one or more further organic solvents, which are differentiated from the alkyl aliphatic monohydric alcohol constituent which is an essential constituent according to certain aspects of the invention, although optional in all other aspects of the invention.
Such further optional organic solvents may include one or more of: alcohols other than the essential lower alkyl aliphatic monohydric alcohol described previously, glycols, acetates, ether acetates, glycerols, as well as polyethylene glycols and glycol ethers. Mixtures of these further optional organic solvents can also be used. Typically such further one or more organic solvents are ones which have no appreciable microbicidal effect and are thus differentiated from the essential alkyl aliphatic monohydric alcohol constituent. Non-limiting examples of useful glycol ethers and examples include those glycol ethers having the general structure R a—O—CH 2—CH(R)—(CH 2)—O n—H, wherein R a is C 1-20 alkyl or alkenyl, or a cyclic alkane group of at least 6 carbon atoms, which may be fully or partially unsaturated or aromatic; n is an integer from 1 to 10, preferably from 1 to 5; each R is selected from H or CH 3; and a is the integer 0 or 1. Specific and preferred solvents are selected from propylene glycol methyl ether, dipropylene glycol methyl ether, tripropylene glycol methyl ether, propylene glycol n-propyl ether, ethylene glycol n-butyl ether, diethylene glycol n-butyl ether, diethylene glycol methyl ether, propylene glycol, ethylene glycol, diethylene glycol monoethyl ether acetate and the like.
When present such further optional one or more organic solvents may be present in any effective amount, preferably in amounts of between about 0.001-10% wt., and preferably between about 0.01-5% wt. Based on the total weight of the treatment composition of which they form a part. The treatment compositions of the invention may include one or more film-forming constituents. Such are advantageously present to provide a coating or barrier layer to dermal surfaces and/or keratinous surfaces. Non-limiting examples of film forming agents can be chosen from anionic compounds, non-ionic compounds, amphoteric compounds, zwitterionic compounds, proteins, viscosity modifiers, cationic polymers, polyamides, polyaminoamides, polyesters, silicone resins, polysaccharides, silicone fluids, polyacrylamides, starches, gums and mixtures thereof. When such are included, they may be present in any effective amount. When present one or more such film forming constituents are preferably present in an amount of between about 0.001-10% wt., and preferably between about 0.01-5% wt.
Based on the total weight of the treatment composition of which they form a part. A further optional constituent which nonetheless may be advantageously present are one or more compounds or materials which absorb a significant percentage (e.g., at least about 75%) of ambient ultraviolet (UVA) light, particularly UVA radiation in the range of about 320-400 nanometers. Nonlimiting examples of preferred UVA radiation absorbing compounds and materials include dibenzoylmethane compounds such as 4-methyldibenzoylmethane, 2-methyldibenzoylmethane, 4-isopropyldibenzoylmethane, 4-tert-butyldibenzoylmethane, 2,4-dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4′diisopropylbenzoylmethane, 4-tert-butyl-4′-methoxydibenzoylmethane, 4,4′-diisopropylbenzoylmethane, 2-methyl-5-isopropyl-4′-methoxydibenzoymethane, 2-methyl-5-tert-butyl-4′-methoxydibenzoylmethane, and the like. When present, such UVA radiation absorbing compounds and materials may be present in any effective amounts, but advantageously when present, are included in the animate surface treatment compositions in amounts of at least about 0.0001% wt., preferably in amounts of from about 0.001% wt.-5% wt. A further optional constituent which nonetheless may be advantageously present are one or more compounds or materials which absorb a significant percentage (e.g., at least about 75%) of ambient ultraviolet (UVB) light, particularly UVB radiation in the range of about 280-320 nanometers. Nonlimiting examples of preferred UVB radiation absorbing compounds and materials include α-cyano-β,β-diphenyl acrylic acid esters, such as 2-ethylhexyl 2-cyano-3,3-diphenylacrylate, as well as octocrylene, which is commercially available as Uvinul® N-539 (ex. Also useful as UVB radiation absorbing compounds include benzylidene camphor derivatives, e.g, 4-methylbenzylidene camphor, which is commercially available as Eusolex® 6300 (ex.
Merck), cinnamate derivatives such as ethylhexyl methoxycinnamate, which is also frequently referred to as Octoxinate or octyl methoxycinnamate. Mono-, di-, and triethanolamine derivatives of such methoxy cinnamates including diethanolamine methoxycinnamate, benzophenone derivatives, Benzophenone 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, and 12. Particularly preferred is where the benzophenone derivative is Benzophenone 3 (also referred to as Oxybenzone) and Benzophenone 4 (also referred to as Sulisobenzone), Benzophenone 5 (Sulisobenzone Sodium), menthyl salicylate derivatives including homomethyl salicylate (also known as Homosalate) or menthyl anthranilate, amino benzoic acid derivatives including PABA, ethyl hexyl dimethyl PABA (Padimate 0), ethyldihydroxypropyl PABA, as well as salicylate derivatives such as octyl salicylate, TEA-salicylcate, DEA-salicylate, and mixtures thereof.
When present such UVB radiation absorbing compounds and materials may be present in any effective amounts, but advantageously when present, are included in the animate surface treatment compositions in amounts of at least about 0.0001% wt., preferably in amounts of from about 0.001% wt.-50% wt. The animate treatment compositions of the invention may optionally further comprise one or more vitamins, antioxidants and/or coenzymes. Nonlimiting examples of vitamins include one or more of Vitamin A and derivatives thereof such as Vitamin A palmitate, acetate, or other esters thereof, as well as Vitamin A in the form of beta carotene, Vitamin C such as ascorbic acid and derivatives thereof, the B vitamins such as thiamine, riboflavin, pyridoxin, and the like, Vitamin E and derivatives thereof such as Vitamin E acetate, nicotinate, or other esters thereof, as well as Vitamin D and Vitamin K. Nonlimiting examples of coenzymes include one or more of thiamine pyrophosphate, flavin adenin dinucleotide, folic acid, pyridoxal phosphate, tetrahydrofolic acid, and the like.
Nonlimiting examples of antioxidants include one or more of potassium sulfite, sodium bisulfite, sodium erythrobate, sodium metabisulfite, sodium sulfite, propyl gallate, cysteine hydrochloride, butylated hydroxytoluene, butylated hydroxyanisole, and the like. When present, such one or more vitamins, antioxidants and/or coenzymes are present in effective amounts, and when present, advantageously comprise at least about 0.001% wt.
Of the composition of which it forms a part. Preferably one or more of said vitamins, antioxidants and/or coenzymes comprise from about 0.002% wt. To about 5% wt. The animate treatment compositions of the invention may optionally further comprise one or more humectants. Nonlimiting examples of such humectants include one or more of di- or polyhydric alcohols such as glycols, sugars, and similar materials. Suitable glycols include alkylene glycols such as propylene, ethylene, or butylene glycol; or polymeric alkylene glycols such as polyethylene and polypropylene glycols, including PEG 4-240, which are polyethylene glycols having from 4 to 240 repeating ethylene oxide units.
Suitable sugars, some of which are also polyhydric alcohols, are also suitable humectants. Examples of such sugars include glucose, fructose, honey, hydrogenated honey, inositol, maltose, mannitol, maltitol, sorbitol, sucrose, xylitol, xylose, and the like. When present, such one or more humectants may be present in any effective amount, and advantageously comprise at least about 0.001% wt.
Of the composition of which it forms a part. When present, preferably the one or more humectants comprise about 0.001-8% wt.
Of the animate surface treatment composition of which it forms a part. The animate surface treatment compositions of the invention may also include one or more Polyquaternium type polymers, as, while such are not necessary to provide the microbicidal benefits of the inventive compositions, such may provide a useful technical benefits, including but not limited to: a film forming benefit, a topical barrier, and additional thickening benefits to the inventive compositions, or other technical benefits. Such materials, are, per se, well known to the art of topical compositions.
Wherein R 1 is hydro, hydroxy, C 1-C 4 alkyl, chloro, nitro, phenyl, or benzyl; R 2 is hydro, hydroxy, C 1-C 6 alkyl, or halo; R 3 is hydro, C 1-C 6 alkyl, hydroxy, chloro, nitro, or a sulfur in the form of an alkali metal salt or ammonium salt; R 4 is hydro or methyl, and R 5 is hydro or nitro. Halo is bromo or, preferably, chloro. Specific examples of phenol derivatives include, but are not limited to, chlorophenols (o-, m-, p-), 2,4-dichlorophenol, p-nitrophenol, picric acid, xylenol, p-chloro-m-xylenol, cresols (o-, m-, p-), p-chloro-m-cresol, pyrocatechol, resorcinol, 4-n-hexylresorcinol, pyrogallol, phloroglucin, carvacrol, thymol, p-chlorothymol, o-phenylphenol, o-benzylphenol, p-chloro-o-benzylphenol, phenol, 4-ethylphenol, and 4-phenolsulfonic acid. Still further useful phenol derivatives include those which may be represented by the structure. Wherein X is sulfur or a methylene group, R 1 and R′ 1 are hydroxy, and R 2, R′ 2, R 3, R′ 3, R 4, R′ 4, R 5, and R′ 5, independent of one another, are hydro or halo.
Specific, nonlimiting examples of diphenyl compounds are hexachlorophene, tetrachlorophene, dichlorophene, 2,3-dihydroxy-5,5′-dichlorodiphenyl sulfide, 2,2′-dihydroxy-3,3′,5,5′-tetrachlorodiphenyl sulfide, 2,2′-dihydroxy-3,5%5,5% 6,6′-hexachlorodiphenyl sulfide, and 3,3′-dibromo-5,5′-dichloro-2,2′-dihydroxydiphenylamine. Of the foregoing, a particularly useful phenol derivative is commonly referred to as triclocarban, or 3,4,4′-trichlorocarbanilide as well as derivatives thereto. When present, one or more such further compounds, constituents or materials which provide an ancillary microbicidal benefit or effect may be present in effective amounts, e.g., in amounts of up to about 5% wt., although depending upon the efficacy of one or more selected such further compounds, constituents or materials are usually effective in reduced amounts, e.g., 0.001-2% wt. Of the treatment composition. The treatment compositions of the invention may optionally include a fragrance constituent, which may be based on natural and/or synthetic fragrances and most commonly are mixtures or blends of a plurality of such fragrances, optionally in conjunction with a carrier such as an organic solvent or a mixture of organic solvents in which the fragrances are dissolved, suspended or dispersed.
Monacor Pa 900 Manual Meat Company
Such may be natural fragrances, e.g, natural extracts of plants, fruits, roots, stems, leaves, wood extracts, e.g. Terpineols, resins, balsams, animal raw materials, e.g., civet and beaver, as well as typical synthetic perfume compounds which are frequently products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type, e.g., benzyl acetate, linalyl acetate, citral, citronellal, methyl cedryl ketone, eugenol, isoeugenol, geraniol, linalool, and Typically it is preferred to use mixtures of different perfume compounds which, together, produce an agreeable fragrance.
Other suitable perfume oils are essential oils of relatively low volatility which are mostly used as aroma components. Examples are sage oil, camomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, lime-blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, labolanum oil and lavendin oil. When present in a treatment composition, in accordance with certain of the preferred embodiments, the fragrance constituent may be present in any effective amount such that it can be discerned by a consumer of the composition, however such is advantageously present in amounts of up to about 1% wt., preferably in amounts of from about 0.00001% wt. To about 0.5% wt., and most preferably in an amount of from about 0.0001% wt. Based on the total weight of the treatment composition of which it forms a part. The animate treatment compositions of the invention may optionally further comprise one or more botanical extracts.
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2000-31926 6 International Search Report for PCT/GB2013/053129 dated Apr. Sagripanti, et al., ', Applied and Environmental Microbiology, vol. 4374-4376, Dec. 8 STN Database Accession No. 2000: 31926 XP-002197632. 9 WPI Abstract Accession No. 10 WPI Abstract Accession No.
11 Written Opinion of the International Searching Authority for PCT/GB2013/053129 dated Apr.